Diabetes drug exhibits promise towards Parkinson’s

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Viewers alongside the eclipse’s path in North America will watch the Moon cross the Solar’s face and block the photo voltaic disk, providing the possibility to see its outer environment by eye.Credit score: Alan Dyer/VW Pics/UIG by way of Getty

On 8 April, researchers will get an unprecedented view of the Solar’s outer wispy environment: the corona. The photo voltaic eclipse seen in elements of North America will coincide with a photo voltaic most — a interval of maximum exercise that happens each 11 years. One analysis group will chase the eclipse from a jet, including 90 extra seconds of statement time to the utmost of 4 minutes and 30 seconds seen by observers on the bottom. One query they’re hoping to reply: why the corona is a lot hotter than the photo voltaic floor. That, says photo voltaic physicist James Klimchuk, is like strolling away from a campfire — however discovering that as a substitute of cooling down, you get hotter.

Nature | 6 min learn

A diabetes drug referred to as lixisenatide has proven promise in slowing the development of Parkinson’s illness. Lixisenatide is within the household of GLP-1 receptor agonists, akin to Ozempic, which have made headlines as weight-loss medication. Within the newest scientific trial, lixisenatide was given to folks with gentle to reasonable Parkinson’s who have been already receiving a typical remedy for the situation. After a yr they noticed no worsening of their signs, in contrast to a management group whose situation did worsen. Additional work is required to scale back the drug’s unintended effects, akin to nausea and vomiting, and to find out whether or not its advantages final. “We’re all cautious. There’s a protracted historical past of attempting various things in Parkinson’s that in the end didn’t work,” says neurologist David Standaert.

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Reference: The New England Journal of Medication paper

The Invoice & Melinda Gates Basis, one of many world’s prime biomedical analysis funders, will from subsequent yr require grant holders to make their analysis publicly accessible as preprints, which aren’t peer reviewed. It’s going to additionally now not pay article-processing expenses (APCs) to publishers with a view to safe open entry, wherein the peer-reviewed model of the paper is free to learn. The change follows criticism that APCs create inequities due to the prices they push onto researchers and funders. “We’ve change into satisfied that this cash might be higher spent elsewhere,” mentioned a Gates consultant.

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Options & opinion

This week marks 30 years for the reason that begin of the 1994 genocide in Rwanda, wherein members of the Hutu ethnic group killed an estimated 800,000 folks from Tutsi communities. The occasion is now one of the vital researched of its variety. These research are tough, not least as a result of as a result of the genocide virtually worn out Rwanda’s tutorial neighborhood. However efforts, particularly by native researchers, are serving to to tell responses to different violent crises and longer-term approaches to therapeutic. Sociologist Assumpta Mugiraneza is main difficult work that gathers testimonies from the genocide — and of the wealthy lives folks had earlier than the atrocity. To consider genocide, she says, “we should dare to hunt humanity the place humanity has been denied”.

Nature | 17 min learn

Two future teachers — a rat and a raven — ponder the destiny of previous primates within the newest quick story for Nature’s Futures collection.

Nature | 6 min learn

Andrew Robinson’s choose of the highest 5 science books to learn this week contains an account of ladies working in nature and a considerate historical past of how our unequal society offers with epidemics.

Nature | 4 min learn

When Brazilian biologist Fernanda Staniscuaski returned from parental depart, her grant purposes began to be rejected as a result of she “was not producing as a lot as my friends”. “Perhaps I used to be by no means meant to be in science,” she recollects considering. Because the founding father of the Dad or mum in Science motion, she is now lobbying for better acceptance of profession breaks. As a primary step, the Brazilian Ministry of Schooling has created a working group to develop a nationwide coverage for moms in academia. “That was enormous,” Staniscuaski says.

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Quote of the day

When the stays of the Australopithecus afarensis nicknamed ‘Lucy’ have been found in 1974, we by no means might have predicted how uncommon such finds can be, says paleoanthropologist Bernard Wooden. Nonetheless, the gathered proof of even older hominins has challenged Lucy’s standing as ‘mom of us all’. (Science | 14 min learn)

In our penguin-puzzle this week, Leif Penguinson is exploring a rock formation on the Barker Dam Path in Joshua Tree Nationwide Park, California. Can you discover the penguin?

The reply will likely be in Monday’s e-mail, all due to Briefing picture editor and penguin wrangler Tom Houghton.

This text is at all times evolving — inform us what you assume! Please ship your suggestions to briefing@nature.com.

Flora Graham, senior editor, Nature Briefing

With contributions by Katrina Krämer, Sarah Tomlin and Sara Phillips

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