Substitution reactions can have actually highly effective results, each good and dangerous, in our our bodies. You would possibly bear in mind substitution reactions as displacement reactions from normal chemistry, however (you guessed it!) in natural chemistry they’re a bit extra difficult. On this episode of Crash Course Natural Chemistry, we’ll study in regards to the two pathways substitution reactions can take: SN1 and SN2 mechanisms, which substrates desire which mechanism, and we’ll apply this data by how substitution reactions make chemotherapy therapies work.
Episode Sources:
Brookes, P., Lawley, P.D. “The Response of Mono-and Di-Useful Alkylating Brokers with Nucleic Acids,” , Biochem. J., 1961, 80, 496-503.
Collection Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Natural Chemistry; eighth ed.; Cengage Studying, Boston, 2018.
Bruice, P. Y., Natural Chemistry, seventh ed.; Pearson Training, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Natural Chemistry, 2nd ed.; Oxford College Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Natural Chemistry, fifth ed.; W. W. Norton & Firm, New York, 2014.
Klein., D., Natural Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Natural Chemistry; fifth ed.; Roberts and Firm Publishers, Colorado, 2009.
McMurry, J., Natural Chemistry, ninth ed.; Cengage Studying, Boston, 2016.
Smith, J. G., Natural chemistry; sixth ed.; McGraw-Hill Training, New York, 2020.
Wade., L. G., Natural Chemistry; eighth ed.; Pearson Training, Inc., United States, 2013.
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