This video doesn’t clarify or counsel easy methods to make medicine, and is solely instructional and theoretical. A crew of chemists lately reported a synthesis of lysergic acid, the precursor of the psychoactive drug LSD, in solely 6 laboratory steps. On this video, we’ll study why LSD-like scaffolds are of curiosity to fashionable drug discovery and look into the chemistry of this brief however candy synthesis.
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Reference:
– Six-Step Synthesis of (±)-Lysergic Acid; https://doi.org/10.1021/acs.joc.2c02564
– Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues via Construction–Exercise Relationship Research; https://doi.org/10.1021/acs.jmedchem.9b01404
00:00 Why science cares about LSD (lysergic acid diethylamide)
02:11 Excessive-level retrosynthesis of lysergic acid
03:13 Ahead synthesis of lysergic acid
06:14 Broader utility to pharmaceutically related buildings
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No info on this channel is meant to be an alternative choice to skilled medical recommendation, prognosis or therapy. All the time search the recommendation of your doctor or different certified well being care supplier with any questions you will have relating to a medical situation or therapy and earlier than endeavor a brand new well being care routine, and by no means disregard skilled medical recommendation or delay in searching for it due to info on Youtube.
Some advisable books on natural synthesis:
– Clayden, Greeves, Warren; Natural Chemistry (fundamental natural chemistry information)
– Wyatt, Warren; Natural Synthesis: The Disconnection Strategy (glorious introduction to retrosynthesis)
– Kurti, Czako; Strategic Functions of Named Reactions in Natural Synthesis (in depth toolkit of useful group reactions and purposes thereof with frequent situations)
– Nicolaou et al; Classics in Whole Synthesis 1-3 (the last word whole synthesis trilogy)
– Nicolaou; Molecules That Modified the World (the world’s most necessary molecules and their influence on on a regular basis life)
– Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking strategies of stereoselective synthesis and utility to synthesis of stereochemically advanced buildings)
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